Biology: Dr. Woodruff
Dr. Ron C. Woodruff

 

Dr. Woodruff
Ph. D., Utah State University
   
Office:     429C Life Sciences Building
Phone:   1-419-372-0376
Email: rwoodru@bgsu.edu
   
Research:
Evolutionary genetics, Role of mutation in evolution and aging, Transposable DNA elements, and Molecular evolution. Drosophila as model organism.
   
Curriculum Vitae
   
 

Research Interests:

 We are involved in two main areas of genetic research with eukaryotic organisms: The role of mutation in evolution and the genetics of transposable DNA elements of Drosophila. In particular, we are interested in the role of premeiotic clusters of mutation in evolution, using experimental and theoretical techniques.

For abstracts of articles, go to: http://www.bgsu.edu/departments/biology/people/faculty/

Selected Publications:

Abstracts for the following articles can be found by going to PubMed on the NCBI website. Type in Woodruff R C to get all the abstracts.

Woodruff, R.C. 2013. An extreme test of mutational meltdown shows mutational firm up instead. Genetica. 141:185-188.

Gontijo, A. M., V. Miguela, M. F. Whiting, R. C. Woodruff and M. Dominguez. 2011. Intron retention in the Drosophila melanogaster Rieske iron sulphur protein gene generated a new protein. Nature Communications. 2:323 doi: 10.1038/ncomms1328.

Gao, J .J., X. R. Pan, J. Hu, L. Ma, J. M. Wu, Y.L. Shao, S. A. Barton, R. C. Woodruff, Y. P. Zhang and Y.X. Fu. 2011. Highly variable recessive lethal or nearly lethal mutation rates during germline development of male Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 108: 15914-15919.

Woodruff, R. C., Mingcai Zhang and Priti Azad. 2011. Adaptation of Drosophila melanogaster to increased NaCl concentration due to dominant beneficial mutations. Genetica 139: 177-186.

Azad, P., Mingcai Zhang, and R. C. Woodruff. Rapid increase in viability due to new beneficial mutations in Drosophila melanogaster. 2010. Genetica 138: 251-263.

Woodruff, R.C., and Mingcai Zhang. 2009. Adaptation from leaps in the dark. Journal of Heredity 100: 7-10.

Ogura, K., R.C. Woodruff, M. Itoh and I.A. Boussy. 2007. Long-term patterns of genomic P element content and P-M characteristics of D. melanogaster in eastern Australia. Genes & Genetic Systems 82: 479-487.

Gong, Y., J.N. Thompson, Jr., and R.C. Woodruff. 2006. Effect of deleterious mutations on lifespan in Drosophila melanogaster. Journal of Gerontology: Biological Sciences 61A: 1246-1252.

Azad, P. and R.C. Woodruff. 2006. Mutation and cloning efficiency. Cloning and Stem Cells 8: 237-239.

Woodruff, R.C., and J.N. Thompson. Jr. 2005. The fundamental theorem of neutral evolution: Rates of substitution and mutation should factor in premeiotic clusters. Genetica 125: 333-339.

Gong, Y., J.N. Thompson, Jr., and R.C. Woodruff. 2005. Deleterious genomic mutation rate for viability in Drosophila melanogaster using concomitant sibling controls. Biology Letters 1: 492-495.

Gong, Y., S. Gu and R.C. Woodruff. 2005. The influence of premeiotic clusters of mutation on indirect estimations of mutation rate. Human Heredity 60: 150-155.

Woodruff, R.C., J.N. Thompson, Jr., and S. Gu. 2004. Premeiotic clusters of mutation and the cost of natural selection. Journal of Heredity 95: 277-283.

 

Teaching Articles:

Grimm, A. J., Kuchcinski, A. F., and R. C. Woodruff. 2012. Effect of genetic background on viability of dominant visible mutations that are also recessive lethals in Drosophila melanogaster. Drosophila Information Service. 95: 157-161.

Kuchcinski, A. F., Grimm, A. J., and R. C. Woodruff. 2012. The identification of unequal crossing-over events at the Bar (B) locus of Drosophila melanogaster. Drosophila Information Service. 95: 162-165.

Woodruff, R. C. and A. M. Boulton. 2011. The identification of nearly neutral mutations in Drosophila melanogaster: The bw75 and bw1 alleles of Buri. Drosophila Information Service. 94: 167-169.

Woodruff, R. C., R. K. Marvin and C. C. Wagner. 2011. Inbreeding depression, loss of genetic variation, and survival in a high salt diet. Drosophila Information Service. 94: 174-176.

Woodruff, R. C. and A. M. Boulton. 2011. Lethal mutations and their elimination by selection in natural populations of Drosophila melanogaster. Drosophila Information Service. 94: 176-180.

Woodruff, R. C. and John P. Russell. 2011. The role of reproduction and recombination in adaptive evolution. Drosophila Information Service. 94: 180-184.

Woodruff, R. C. and John P. Russell. 2011. Spontaneous and gamma ray induced chromosome breakage in Drosophila melanogaster. Drosophila Information Service. 94: 184-186.

Boulton, A. M. and R. C. Woodruff. 2010. Experimental observation of underdominance (heterozygous disadvangage) in Drosophila Information Service. 93: 245-255.

Marvin, R. K., C. C. Wagner and R. C. Woodruff. 2010. Confirmation of the Calvin B. Bridges study: Based on nondisjunction, the white gene is located on the X chromosome of Drosophila melanogaster. Drosophila Information Service. 93: 261-166.

Woodruff, R. C. and Katherine D. Onasch. The identification of hidden genetic variation
(recessive visible mutations) in a natural population of Drosophila melanogaster. 2009.
Drosophila Information Service. 92: 160-164.

Rex, Caitlin M., Sarah J. Rossiter, Amanda C. Lyons and R. C. Woodruff. Negative
synergistic epistasis in Drosophila melanogaster. 2009. Drosophila Information Service. 92: 151-154.

Benson, J.L., A.M. Boulton, C.W. Coates, A.C. Lyons, S.J. Rossiter and R. C. Woodruff. Rare male mating advantage in Drosophila melanogaster. 2009. Drosophila Information Service. 92: 155-160.

Onasch, Katherine D. and R. C. Woodruff. 2008. Experimental observation of inbreeding depression and heterosis in Drosophila melanogaster. Drosophila Information Service. 91: 151-155.

Onasch, Katherine D, Natalie Wiseman, Bethany Robinson, Mingcai Zhang, and R. C. Woodruff. 2008. Experimental observation of overdominance (heterozygous advantage) in Drosophila melanogaster. Drosophila Information Service. 91: 169-178.

Robinson, Bethany, Natalie Wiseman, Mingcai Zhang, Cynthia J. Staber and R. C.Woodruff. 2008. Identification of selfish genetic elements in natural populations of Drosophila melanogaster. II. Segregation Distorter (SD). Drosophila Information Service. 91: 179-182.

Thompson, James N., Jr. Clayton N. Hallman, Christopher C. Challis, Jane T. Ma, Kyley K. Makanani, Anna L. McGahan, Whitney D. Nall, Patience O. Ozor, Sean P. Rogers, Katherine L. Shoush, Jessica L. Turner, Hunter J. Wernick, Dusty M. Wiles, Rachel S. Yi, Tyler W. Kallsen, Michael J. Hessler, Barbara Sfiejko-Mroczka, and R. C. Woodruff. 2008. A classroom test of predictions about Segregation Distorter (SD) activity in Drosophila. Drosophila Information Service. 91: 183-185.

Onasch, Katherine D. and R. C. Woodruff. 2007. Changes in linkage disequilibrium over time in Drosophila melanogaster for two sex-linked loci. Drosophila Information Service. 90: 177-186.

Robinson, Bethany, Natalie Wiseman and R. C. Woodruff. 2007. Identification of selfish genetic elements in natural populations of Drosophila melanogaster. I.P DNA elements. Drosophila Information Service. 90: 172-176.

Toth, Cynthia L, Jessica L. Heintzelman and R. C. Woodruff. 2007. Ultraviolet (UV) light induced mutations in Drosophila melanogaster. Drosophila Information Service. 90: 169-171.

Thompson, J. N., jr. Clayton N. Hallerman, Jenna J. Hellack and R. C. Woodruff. 2006. Measuring natural selection using alcohol dehydrogenase alleles. Drosophila Information Service. 89: 148-149.

Zhang, Mingcai and R. C. Woodruff. 2006. Confirmation of the Bateman’s principle: a sexual selection exercise. Drosophila Information Service. 89: 143-148.

Woodruff, R. C. and J. N. Thompson, jr. 2005. Response to selection in the presence and absence of genetic variation in Drosophila melanogaster. Drosophila Information Service. 88: 139-143.

Morgan, E., R. C. Woodruff and J. N. Thompson, jr. 2004. The interchromsomal effect on recombination in Drosophila melanogaster. Drosophila Information Service, 87: 115-117.

Azad, P., R. C. Woodruff and J. N. Thompson, jr. 2004. Deleterious mutations in natural populations of Drosophila melanogaster. Drosophila Information Service, 86: 165-168.

Woodruff, R. C. and James N. Thompson, jr. 2002. Use of the Drosophila melanogaster zeste screen to identify aneuploidy induced by cold treatment. Drosophila Information Service, 85: 149-151.

Gu, Sheng, Yi Gong, Matthew Smith and R. C. Woodruff. 2002. The dominance value of the Sb allele in Drosophila melanogaster. Drosophila Information Service, 85: 143-149.

Woodruff, R. C. and J. N. Thompson, jr. 2001. A one-generation, white-peach assay for mariner DNA element activity in Drosophila simulans. Drosophila Information Service, 84: 213-215.

Thompson, J. N., jr., R. C. Woodruff, S. B. Gray, G. S. Hendrix and J. J. Hellack. 2000. Cellulose acetate measurement of Adh allele frequencies is a simple exercise in population genetics. Drosophila Information Service 83: 203-205.

Woodruff, R. C. and J. N. Thompson, jr. 1999. A one-generation assay of induced genetic damage. Drosophila Information Service, 82: 140-141.

Woodruff, R. C. and J. N. Thompson, jr. 1997. A teaching exercise combining Mendelian genetics and gene therapy concepts in Drosophila. Drosophila Information Service 80: 107-108.