Currently, we are studying the blood coagulation cascade and are examining the effect of acetaldehyde upon the coagulation components. This relates directly to the effect of alcohol metabolites upon the enzymes, zymogens, protease inhibitors and glycosaminoglycans, such as heparin. Additionally, we are chemically modifying heparin and studying the anticoagulant effects of its analogs. Finally, the effect of acetaldehyde on hypertension, hypotension, pancreatitis, and emphysema are being explored.
In separate studies, we are quantitating the effect of protamine sulfate and other small peptides with hormonal potential on the interaction of blood coagulation factors with antithrombin III.
A.S. Brecher, S.J. Murrey, K.D. Gray, and J.N. Poulimenos. Anticoagulant effect of captopril. J. Cardiovascular Pharmacol., 2007, In Press.
A.S. Brecher and R. Dubord. Captopril and Lisinopril decrease acetaldehyde effects upon prothrombin time. Digestive Diseases & Sciences, 2007, In Press.
A.S. Brecher and R. Dubord. Effect of acetaldehyde upon cathepsin G and chymase. NRAS implications. Digestive Diseases & Sciences, 2007, In Press.
E.A. Suchocki and A.S. Brecher. The effect of acetaldehyde on human plasma factor XIII function. Dig. Dis. Sci. 2007, Apr. 10 (Epub ahead of print).
A.S. Brecher, A.R. Moon, and K.D. Gray. The effect of acetaldehyde-glycosaminoglycan mixtures upon Factor IXa and Factor IX-Deficient Plasma. ALCOHOL, (2006) 39, 97-104.