Controlled, site-specific application of a compound of interest represents a major problem in drug delivery. For the best treatment, you need precise control over the application, distribution, and pharmacokinetics of the drug in order to know where and when the drug is acting effectively. One way to overcome this limitation is photochemistry. Photochemistry offers a tool with which one can direct chemical reactions with light stimulus.
Research in the group will involve synthesis of inorganic molecules and nanoparticles as well as engineering of photo-chemical drug-delivery devices and preliminary screening of the bioactivity of the photo-responsive materials.
Specific research topics are:
- Development of photo-active metallosurfactant materials.
- Development and characterization of photo-responsive compounds for selective release of caged compounds.
- Nanoparticle synthesis and development of multi-functional materials for biological applications.
A. D. Ostrowski; B.F.Lin; M.V.Tirrell; P.C.Ford. “Liposome encapsulation of a photochemical NO precursor for controlled nitric oxide release and simultaneous fluorescence imaging,” Molecular Pharmaceutics, 2012, Article ASAP, DOI: 10.1021/mp300139y
E.M. Chan; G.Han; J.D.Goldberg; D.J. Gargas; A. D. Ostrowski; P.J. Schuck; B.E.Cohen; D.J. Milliron; " Combinatorial discovery of lanthanide-doped nanocrystals with spectrally pure upconverted emission,” Nano Lett 2012, 12, 3839–3845.
A. D. Ostrowski; E.M. Chan; D.J. Gargas; E. M. Katz; G. Han; P. J. Schuck; D. J. Milliron; B. E. Cohen. “Controlled synthesis and single particle imaging of bright, sub-10 nm lanthanide-doped upconverting nanocrystals,” ACS Nano 2012, 6, 2686–2692.
A. D. Ostrowski; S. J. Deakin; B. Azhar; T. W. Miller; N. Franco; M. M. Cherney; A. J. Lee; J. N. Burstyn; J. M. Fukuto; I. L. Megson; P. C. Ford. "Nitric Oxide Photogeneration from trans-Cr(cyclam)(ONO)2+ in a Reducing Environment. Activation of Soluble Guanylyl Cyclase and Arterial Vasorelaxation," J. Med. Chem. 2010, 53, 715–727.
A. D. Ostrowski and P. C. Ford. "Metal complexes as photochemical nitric oxide precursors: Potential applications in the treatment of tumors." Dalton Trans., 2009, 10660 – 10669.